Top Abstract Purchase Related
Home
>
Node
>
Subnode

Frequent p53 gene mutations and novel alleles in familial breast cancer

Glebov, O.K.; McKenzie, K.E.; White, C.A.; Sukumar, S.

Cancer Research 54(14): 3703-3709

1994

ISSN/ISBN: 0008-5472
PMID: 8033087
Document Number: 426679
Mutations in the p53 gene were detected in 58% of tumor DNAs of patients with a family history of breast cancer (FHBC) compared to 13% with sporadic breast cancer. Seven of 18 FHBC tumors contained the same G to C transversion in codon 156. Novel alleles of altered length were seen in one or more loci on chromosome 17 in 15 of 18 patients with FHBC but only in a single locus in 8 of 14 patients with sporadic breast cancer. The frequency of tumors with mutations in p53, often multiple. accompanied by the appearance of multiple altered-length alleles suggest that DNA replication or repair defects may presage genomic instability in cases with FHBC.

Document emailed within 1 workday
Secure & encrypted payments

1997: Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium Lancet 349(9064): 1505-1510
Haraldsson, K.; Loman, N.; Zhang, Q.X.; Johannsson, O.; Olsson, H.; Borg, A. 1998: BRCA2 germ-line mutations are frequent in male breast cancer patients without a family history of the disease Cancer Research 58(7): 1367-1371
Devilee, P.; van Vliet, M.; Bardoel, A.; Kievits, T.; Kuipers-Dijkshoorn, N.; Pearson, P.L.; Cornelisse, C.J. 1991: Frequent somatic imbalance of marker alleles for chromosome 1 in human primary breast carcinoma Cancer Research 51(3): 1020-1025
Grann, V. 1997: Risk of breast cancer in carriers of BRCA gene mutations New England Journal of Medicine 337(11): 788
Vancutsem, P.M.; Lazarus, P.; Williams, G.M. 1994: Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen Cancer Research 54(14): 3864-3867
Bignell, G.R.; Barfoot, R.; Seal, S.; Collins, N.; Warren, W.; Stratton, M.R. 1998: Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer Cancer Research 58(7): 1384-1386
Dueñas González, A.; Cruz Hernández, J.J.; Abad Hernández, M.M.; Ramos, M.; González Sarmiento, R. 1996: Greater sensitivity of the PCR-SSCP technique compared with immunohistochemistry for the detection of exon 5 and 6 mutations of gene 53 in breast cancer Medicina Clinica 106(19): 721-724
Kurtz, J.M. 2000: Are local recurrences after breast conserving therapy more frequent in patients with BRCA1/BRCA2 mutations? Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft . 176(9): 433-434
Weniger, M.A.; Melzner, I.; Menz, C.K.; Wegener, S.; Bucur, A.J.; Dorsch, K.; Mattfeldt, T.; Barth, T.F.E.; Möller, P. 2006: Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation Verhandlungen der Deutschen Gesellschaft für Pathologie 90: 210-215
Liu, Y.; Koda, Y.; Soejima, M.; Uchida, N.; Kimura, H. 1996: PCR analysis of Lewis-negative gene mutations and the distribution of Lewis alleles in a Japanese population Journal of Forensic Sciences 41(6): 1018-1021
Gong, K.; Zhang, Z.; Xin, D. 2001: Frequent somatic mutations of the von Hippel-Lindau tumor suppressor gene in primary sporadic human renal clear cell carcinomas Zhonghua Yi Xue Za Zhi 81(3): 142-144
Jacob, A.N.; Kandpal, G.; Kandpal, R.P. 1996: Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12 Oncogene 13(1): 213-221
Freiberger, T.; Kuhrová, V.; Kozák, L.; Soska, V.; Pekarík, V.; Mĕrínská, L.; Fajkusová, L.; Francová, H. 1998: Direct detection of mutations in the LDL receptor gene in patients with familial hypercholesterolemia Casopis Lekaru Ceskych 137(24): 750-752
Zajac, V.; Kovác, M.; Kirchhoff, T.; Stevurková, V.; Tomka, M. 2002: The most frequent APC mutations among Slovak familial adenomatous polyposis patients. Adenomatous polyposis coli Neoplasma 49(6): 356-361
Kotze, M.J.; Langenhoven, E.; Warnich, L.; du Plessis, L.; Marx, M.P.; Oosthuizen, C.J.; Retief, A.E. 1989: The identification of two low-density lipoprotein receptor gene mutations in South African familial hypercholesterolaemia South African Medical Journal 76(8): 399-401
Meshkov, A.N.; Stambol'skiĭ, D.V.; Krapivner, S.R.; Bochkov, V.N.; Kukharchuk, V.V.; Malyshev, P.P. 2004: Low density lipoprotein receptor gene mutations in patients with clinical diagnosis of familial hypercholesterolemia Kardiologiia 44(9): 58-61
Tengrup, I.; Nittby, L.T.; Christiansson, I.; Laurin, M. 1999: Problems with arms are common after breast surgery. Lymphedema is a frequent complication in elderly women treated for breast cancer Lakartidningen 96(46): 5089-5091
Miyaki, M.; Konishi, M.; Kikuchi-Yanoshita, R.; Enomoto, M.; Tanaka, K.; Takahashi, H.; Muraoka, M.; Mori, T.; Konishi, F.; Iwama, T. 1993: Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis Cancer Research 53(21): 5079-5082
Liu, W.-l.; Xie, W.-l.; Hu, D.-Y.; Zhu, T.-g.; Li, Y.-t.; Sun, Y.-h.; Li, C.-l.; Li, L.; Li, T.-c.; Bian, H.; Tong, Q.-g.; Yang, S.-n.; Fan, R.-y.; Cui, W. 2006: Analysis of MYH7, MYBPC3 and TNNT2 gene mutations in 10 Chinese pedigrees with familial hypertrophic cardiomyopathy and the correlation between genotype and phenotype Zhonghua Xin Xue Guan Bing Za Zhi 34(3): 202-207
Bremer, M.; Steinmann, D.; Dork, T.; Borger, J.; Rades, D.; Karstens, J.H. 2001: Bilaterales Mammakarzinom und Lokalrezidiv: Prävalenz von BRCA-1- und BRCA-2-Genmutationen an einem unselektionierten Kollektiv - Bilateral breast cancer and local relapse: a hospital-based study of the prevalence of BRCA 1 and BRCA 2 gene Mutations Strahlentherapie und Onkologie 177(7): 325-329