Truncated tau protein as a new marker for Alzheimer's disease
Novák, M.
Acta Virologica 38(3): 173-189
1994
ISSN/ISBN: 0001-723X PMID: 7817900 Document Number: 426350
Molecular analysis of histological hallmarks (neurofibrillary tangles, neuritic plaques, neuropil threads and dystrophic neurites) of Alzheimer diseased brain tissues showed that these lesions contain paired helical filaments. Their major constituent is microtubule associated protein tau that is in an abnormally hyperphosphorylated and truncated state. These diseased forms of tau protein are unable to promote full microtubule assembly. Understanding of the molecular basis of the processes leading to the modifications of tau proteins and paired helical filament formation will form a firm step toward rational drug development and the cure of the Alzheimer's disease.