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Optimal induction and maintenance of the hypertensive state an important factor in clinical advantages of angiotensin Ii induced hypertension chemotherapy (IHC)

Sato, H.; Hoshi, M.; Sugiyama, K.; Urushiyama, M.; Ishizuka, K.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(Suppl 4): 459-461

1994

ISSN/ISBN: 0385-0684
PMID: 7802450
Document Number: 425790
Angiotensin II induced hypertension chemotherapy (IHC) is a drug delivery system in which the functional difference of microcirculation between tumor and normal tissue was applied. IHC records of the patients with advanced gastrointestinal cancer, admitted in our hospitals were analysed according to the patterns of the maintenance level and range of blood pressure. Those who were possible to get ambulatory life had significantly good response and long survival in addition to better performance status before IHC, comparing with those who had continued admission life. An optimal range of elevation level and stable maintenance of hypertension induced by the infusion of angiotensin II was essentially required to obtain a good response.

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