Clinical investigation of low dose levonorgestrel releasing vaginal ring
Gao, J.
Sheng Zhi Yu Bi Yun 7(3): 62-65
1987
ISSN/ISBN: 0253-357X PMID: 12315174 Document Number: 425739
Contraceptive effectiveness and side effects were observed in 108 women, aged 21-35, using low dose levonorgestrel releasing vaginal rings. 106 of 108 were primiparous and the others were multiparous. Follow-up occurred in 1 year and no cases were lost. The rings, containing 5 mg of levonorgestrel with a releasing rate of 20.0+-3.5 mcg/day, were usable for 90 days and were provided by WHO. They were inserted on the 4th-6th day of a cycle and observed for cumulative net rate, expulsion rate, bleeding and removal rate. 31 of 108 cases stopped for various reasons, a discontinuation rate of 26.9%. Among the 31 terminated cases, 4 had become pregnant during the experiment, 4 were due to pain in using the ring, 5 were the result of expulsion, 12 were due to bleeding and menstruation disorders, and the others were attributed to non-medical reasons such as unusual feelings during intercourse. Bleeding was the most common side effect and the primary cause for removal. Results showed that menstrual blood loss gradually lessened after insertion.