Effects of opioid analgesics on pulmonary ventilation and metabolism in patients with acute postoperative pain
Nikoda, V.V.; Petrov, R.O.; Sandrikov, V.A.; Chizhov, A.I.
Anesteziologiia i Reanimatologiia 4: 28-29
1994
ISSN/ISBN: 0201-7563 PMID: 7802313 Document Number: 425105
Opioid analgesics buprenorphine, nubain, and morphine were used in 33 patients suffering from acute postoperative pain on days 1-3 after operations on the lungs, heart and main vessels, abdominal organs. Buprenorphine was used in dose 0.01 mg/kg, nubain in dose 0.3 mg/kg, and morphine in dose 0.3 mg/kg. Effects of opioid analgesics on O2 consumption, carbon dioxide exhalation, minute respiration volume, and total energy metabolism were monitored. Effects of buprenorphine on metabolism and ventilation were the most manifest: it lead to reduction of metabolism by 26.2% and minute respiration volume by 36%. Nubain had no noticeable effect on metabolism or ventilation parameters. Morphine lead to moderately expressed changes in metabolism and ventilation reducing metabolism by 12.5% and minute respiration volume by 10.3%.