The effect of (-) -4- (2-hydroxy-3 (N-isopropylamino) -propoxyimino) -cis-carane on basal and forskolin-stimulated accumulation of cyclic AMP in the cerebral cortical slices of the rat
Librowski, T.; Nalepa, I.; Czarnecki, R.; Vetulani, J.
Journal of Pharmacy and Pharmacology 46(5): 393-394
1994
ISSN/ISBN: 0022-3573 PMID: 8083817 Document Number: 425008
(-)-4-(2-Hydroxy-3(N-isopropylamino)-propoxyimino)cis-carane, a local anaesthetic and platelet aggregation inhibitor which is much more potent than lignocaine, facilitated forskolin-induced cyclic (c) AMP accumulation in cerebral cortical slices of the rat. Lignocaine was ineffective in this respect. It is hypothesized that a cAMP-related mechanism may be involved in increased efficacy of the compound.