Change in level and saturation by iron of blood plasma transferrin in hereditary retinal degeneration in rats
Efimova, M.G.; Nikolaeva, I.A.; Shushakova, N.D.
Biulleten' Eksperimental'noi Biologii i Meditsiny 118(7): 24-26
1994
ISSN/ISBN: 0365-9615 PMID: 7919266 Document Number: 424458
Composition and properties of plasma transferrin were studied in Campbell rats with hereditary retinal degeneration and healthy Wistar rats at different postnatal stages. On the twentieth day of life, the content of nonhemic iron in the blood plasma of Campbell rats proved to be 1.9 times lower than that in healthy animals. Transferrin level in the blood plasma of sick animals was 4.3 times lower, and the degree of iron saturation of transferrin 2.3 times higher compared to those in healthy rats during the same period. These discrepancies in iron levels and iron saturation of transferrin disappeared by the forty-fifth and ninetieth days of life. No differences were observed in the iron saturating ability of apotransferrins in sick and healthy animals.