Molecular analysis of the LDL receptor
Yokode, M.; Kita, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 52(12): 3170-3176
1994
ISSN/ISBN: 0047-1852 PMID: 7853707 Document Number: 424111
The LDL receptor is a cell surface glycoprotein that regulates plasma cholesterol by mediating endocytosis of LDL, the major cholesterol transport protein in human plasma. Mutations in the LDL receptor gene cause familial hypercholesterolemia (FH). The LDL receptor was purified in 1982, its cDNA was cloned in 1984 by Yamamoto et al, and its gene was isolated in 1985 by Sudhof et al. This review attempts to focus on the molecular basis of the LDL receptor pathway and its regulatory roles in cholesterol homeostasis in the body.