Regressive leukoencephalopathy induced by an overdose of cyclosporine A
Mabin, D.; Fourquet, I.; Richard, P.; Esnault, S.; Islam, M.S.; Bourbigot, B.
Revue Neurologique (Paris) 149(10): 576-578
1993
ISSN/ISBN: 0035-3787 PMID: 8023077 Document Number: 422104
We report a case of leucoencephalopathy with tremor and generalized motor seizures a few days after introduction of cyclosporin A (Cy A) in a kidney recipient. There was a relationship between acute neurological symptoms and high and sudden blood level of Cy A (1,260 ng/ml; therapeutic range: 120-275 ng/ml). White-matter hypodensities at CT scanning and severe slow-waves abnormalities at EEG were present. All neurological symptoms were reversible after Cy A level was lowered. Three months later, a blood Cy A level at 217 ng/ml due to nicardipine co-administration resulted in severe tremor and was reversed by decreasing blood Cy A level to 126 ng/ml.