Changes in the content of phospholipids and their metabolic products in the blood and tissues of patients with endometriosis interna and cancer of the corpus uteri
Sliusar', N.N.; Kulakov, V.I.; Damirov, M.M.; Kargapolov, A.V.
Akusherstvo i Ginekologiia 1993(4): 38-40
1993
ISSN/ISBN: 0300-9092 PMID: 8250116 Document Number: 421825
Levels of phospholipids, phosphoinosites, phosphatidylinosite-3-phosphates, diacylglycerols, arachidonic acid, prostaglandins E, F, J, and thromboxane A2 in patients with endometriosis and cancer of the corpus uteri were found to differ from those in healthy women. Biochemical parameters of whole blood and myometrial tissue of endometriosis patients differ significantly from those of patients with corpus uteri cancer. The authors suggest that reduction of phosphatidylinosite and phosphatidulinosite-3-phosphate levels in whole blood and their parallel increase in myometrial tissue are conducive to cellular proliferation and malignant degeneration.