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Isocitrate dehydrogenases: forms, localization, properties, and regulation

Popova, T.N.

Biokhimiia 58(12): 1861-1879

1993

ISSN/ISBN: 0320-9725
PMID: 8292648
Document Number: 421577
The literary and original data concerning the localization, properties, activity regulation and physiological role of NAD- and NADP-dependent isocitrate dehydrogenases are reviewed. Possible mechanisms of regulation of anabolic and catabolic cellular processes at the isocitrate dehydrogenase level are discussed. The data on the structure and chemical modification of the active center functional groups suggest that isocitrate dehydrogenases isolated from various sources differ in their catalytic properties. The pathways and prospectives in practical application of the enzymes are considered.

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