Expression of P53 protein in cutaneous melanoma
Casazza, S.; Gambini, C.; Tunesi, G.; Rovida, S.; Caruso, F.; Pastorino, A.; Canepa, M.
Pathologica 85(1097): 335-342
1993
ISSN/ISBN: 0031-2983 PMID: 8233650 Document Number: 421571
P53 protein in cutaneous melanoma. We report the results of an immunohistochemical analysis about the nuclear phosphoprotein P53 expression performed on 48 primary and 10 metastatic cutaneous melanoma in order to assess the prevalence of the expression of mutant P53 protein (m-P53) in this skin tumour. In our study m-P53 was found in about 46% of primary tumours without any significant relationship with the corresponding metastatic lesions. Therefore the P53 count in cutaneous melanoma is not a prognostic marker of tumour spread and aggressiveness.