Corticosteroid treatment regimes and growth hormone secretion in congenital adrenogenital syndrome
Balsamo, A.; Cicognani, A.; Guacci, P.; Cassio, A.; Cacciari, E.
La Pediatria Medica e Chirurgica Medical and Surgical Pediatrics 15(6): 585-587
1993
ISSN/ISBN: 0391-5387 PMID: 8197019 Document Number: 421392
11 patients with 21-hydroxylase deficiency were treated with three different corticosteroids and two different distributions of therapy during daytime. We found that: 1) a higher dose of steroid in the evening had a markedly inhibitory effect on nocturnal GH secretion; 2) of the steroids we used, dexamethasone caused the greatest reduction in nocturnal GH secretion; 3) in this study adrenal hormones seem less influenced by the different distribution of the corticosteroids during the 24 hours period.