Beta-cyclodextrin as a direct compression excipient compared to conventional ones
Saleh, S.I.
Journal de Pharmacie de Belgique 48(5): 371-377
1993
ISSN/ISBN: 0047-2166 PMID: 8120790 Document Number: 421306
Beta-Cyclodextrin was evaluated as a direct compression excipient and compared to conventional excipients. The measured physical properties included particle size and particle size distribution, flowability, bulk density, and hygroscopicity. Compression characteristics were evaluated by measuring compactibility, compression force-hardness profiles and compression force requirements. The materials studied were directly compressed into tablets and the produced tablets were evaluated with regard to uniformity of weight, disintegration time, crushing strength and friability. The results suggest that beta-cyclodextrin is a good candidate as a direct compression excipient.