Effects of erythropoietin on strength and functional status of patients on hemodialysis
Guthrie, M.; Cardenas, D.; Eschbach, J.W.; Haley, N.R.; Robertson, H.T.; Evans, R.W.
Clinical Nephrology 39(2): 97-102
1993
ISSN/ISBN: 0301-0430 PMID: 8448925 Document Number: 420728
The strength, endurance, and functional status of 15 anemic (HCT 21.2 +/- 4.6) hemodialysis patients was quantified prior to the administration of erythropoietin (epoetin) and after the anemia was partially corrected (HCT 35.4 +/- 2.3). Subjects showed significant increases in strength, measured isometrically (p < .01) and isokinetically (p < .01 at four of five speeds). They also demonstrated improved endurance and rated their functional ability higher. Anemia contributes to significant debilitation in hemodialysis patients and, when reversed with epoetin therapy, results in significantly improved muscle function and endurance.