Molecular biology of Wilms' tumor
Koo, H.P.; Hensle, T.W.
Urologic Clinics of North America 20(2): 323-331
1993
ISSN/ISBN: 0094-0143 PMID: 8388135 Document Number: 419490
This article reviews recent advances in the molecular biology in cytogenetics of Wilms' tumor. The role of tumor suppressor genes in the development of tumors is reviewed and the mapping and genetic loci associated with Wilms' tumor is elucidated. The identification of the WT1 gene as well as the normal expression of that gene is reviewed. Identification of the putative WT2 gene is also reviewed.