Efficacy of xiaoxingzhang guttae ophthalmic eye drops in the treatment of experimental herpes simplex keratitis
Zhang, J.M.; Lin, P.F.; Chen, L.L.; Tang, L.H.; Hong, X.Q.; Liang, B.X.; Chen, H.S.; Teng, L.
Zhongguo Zhong Yao Za Zhi 18(1): 49-52; 64
1993
ISSN/ISBN: 1001-5302 PMID: 8391822 Document Number: 418409
The new guttae ophthalmic Xiaoxingzhang (XXZ) was extracted from Radix Actinidiae, a traditional Chinese herbal drug. The 50% inhibition concentration (IC50) of XXZ on type I Herpes Simplex Virus (HSV-1) in virus cell cultures is 165.48-174.73 micrograms/ml. However, XXZ concentrations greater than 400 micrograms/ml did not cause any microscopically visible disruption of vero cells. The efficacy of XXZ in the treatment of experimental Herpes Simplex Keratitis (HSK) in rabbits is higher than that of idoxuridine. The effective doses of XXZ are not toxic to corneal epithelium. The results suggest that XXZ as a new anti-HSV preparation is potentialy useful in the treatment of patients with HSK.