Amyloid deposition in Alzheimer's disease
Meena-Leist, C.E.; Parker, J.C.
Annals of Clinical and Laboratory Science 23(3): 173-177
1993
ISSN/ISBN: 0091-7370 PMID: 8323250 Document Number: 417863
Alzheimer's disease (AD), a progressive neurodegenerative disorder, accounts for approximately 60 percent of all victims of dementia and affects greater than 10 percent of the population over 65 years old. Although the cause is unknown, there is evidence that beta-amyloid plays an important role in its pathogenesis. The deposition of this type of amyloid in the brain and its implications in AD are discussed.
Document emailed within 1 workday
Related Documents
DE Felice, F.G.; Houzel, J-Christophe.; Garcia-Abreu, Jé.; Louzada, P.Roberto.F.; Afonso, R.C.; Meirelles, M.Nazareth.L.; Lent, R.; Neto, V.Moura.; Ferreira, Sérgio.T. 2001: Inhibition of Alzheimer's disease β-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy FASEB Journal 15(7): 1297-1299Mastaglia, F.L.; Masters, C.L.; Beyreuther, K.; Kakulas, B.A. 1989: Deposition of Alzheimer's disease amyloid (A4) protein in the cerebral cortex in Parkinson's disease Progress in Clinical and Biological Research 317: 475-484
Beauquis, J.; Vinuesa, A.; Pomilio, C.; Pavía, P.; Saravia, F. 2014: Hippocampal and cognitive alterations precede amyloid deposition in a mouse model for Alzheimer's disease Medicina 74(4): 282-286
Davies, L.; Wolska, B.; Hilbich, C.; Multhaup, G.; Martins, R.; Simms, G.; Beyreuther, K.; Masters, C.L. 1988: A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques Neurology 38(11): 1688-1693
Yilmazer-Hanke, D.M. 1998: Alzheimer's disease. The density of amygdalar neuritic plaques is associated with the severity of neurofibrillary pathology and the degree of beta-amyloid protein deposition in the cerebral cortex Acta Anatomica 162(1): 46-55
Fukatsu, R.; Tsuzuki, K.; Hayashi, Y.; Takamaru, Y.; Sasaki, N.; Yoshida, T.; Hatakeyama, Y.; Fuji, N.; Takahata, N. 1997: Recent advances in Alzheimer's disease research--amyloid precursor protein trafficking, processing, and mutations in Alzheimer's disease linked genes Hokkaido Journal of Medical Science 72(1): 3-11
Miyakawa, T. 1988: Brain pathology in Alzheimer's disease. Ultrastructure of amyloid fibrils in Alzheimer's disease and Down's syndrome Nihon Rinsho. Japanese Journal of Clinical Medicine 46(7): 1471-1474
Narindrasorasak, S.; Altman, R.A.; Gonzalez-DeWhitt, P.; Greenberg, B.D.; Kisilevsky, R. 1995: An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease Laboratory Investigation; A Journal of Technical Methods and Pathology 72(3): 272-282
Mera, S.L. 1991: Aluminium, amyloid, and Alzheimer's disease Medical Laboratory Sciences 48(4): 283-295
Kubo, Y.; Morita, T.; Koda, Y.; Hirasawa, Y. 1990: Two types of glomerular lesion in non-amyloid immunoglobulin deposition disease: a case report of IgD-lambda myeloma Clinical Nephrology 33(6): 259-263
Storey, E.; Masters, C.L. 1995: Amyloid, aluminium and the aetiology of Alzheimer's disease Medical Journal of Australia 163(5): 256-259
Octave, J.N. 1995: The amyloid peptide precursor in Alzheimer's disease Acta Neurologica Belgica 95(4): 197-209
Gurwitz, D. 1996: Beta-Amyloid vasoactivity in Alzheimer's disease Lancet 347(9013): 1492
Salbaum, J.M.; Weidemann, A.; Masters, C.L.; Beyreuther, K. 1989: The promoter of Alzheimer's disease amyloid A4 precursor gene Progress in Clinical and Biological Research 317: 277-283
Ishii, T. 1991: Amyloid (senile) plaques in Alzheimer's disease brain Nihon Rinsho. Japanese Journal of Clinical Medicine 49(4): 945-949
Haas, C.; Hung, A.Y.; Citron, M.; Teplow, D.B.; Selkoe, D.J. 1995: beta-Amyloid, protein processing and Alzheimer's disease Arzneimittel-Forschung 45(3a): 398-402
Haan, J.; Timmers-den Hollander, L.; Timmers, W.F.; Timmers, J.; Roos, R.A. 1991: Hereditary cerebral amyloid angiopathy and Alzheimer's disease Nederlands Tijdschrift Voor Geneeskunde 135(3): 83-87
Tanaka, S.; Nakamura, S.; Ueda, K. 1990: Expression of amyloid beta-protein gene in Alzheimer's disease Rinsho Byori. Japanese Journal of Clinical Pathology 38(5): 489-493
Tamaoka, A. 2013: The pathophysiology of Alzheimer's disease with special reference to "amyloid cascade hypothesis" Rinsho Byori. Japanese Journal of Clinical Pathology 61(11): 1060-1069
Gui, L.; Li, W. 1998: Amyloid protein precursor gene and neuron apoptosis of Alzheimer's disease Zhonghua Yi Xue Za Zhi 78(8): 582-583