Heterocyclic modulators of the NMDA receptor
Pellicciari, R.; Natalini, B.; Costantino, G.; Garzon, A.; Luneia, R.; Mahmoud, M.R.; Marinozzi, M.; Roberti, M.; Rosato, G.C.; Shiba, S.A.
Farmaco 48(2): 151-157
1993
ISSN/ISBN: 0014-827X PMID: 8494596 Document Number: 416723
The design of new heterocyclic derivatives as modulatory agents at EAA receptors is described. In particular, the potent and selective activity at the NMDA receptor of trans-4-hydroxypipecolic acid-4-sulfate, as well as the neuroprotective properties of substituted thiokynurenates, a new class of competitive antagonists at the glycine site of the NMDA receptor complex, are reported.