Long-term toxicity of a hydrogelic occlusive device in the isthmus of the human oviduct. a light microscopic study
Brundin, J.; Sandstedt, B.
Acta Pathologica Microbiologica et Immunologica Scandinavica. Section a Pathology 93(3): 121-126
1985
ISSN/ISBN: 0108-0164 PMID: 3893029 DOI: 10.1111/j.1699-0463.1985.tb03930.xDocument Number: 416118
Ten women applying for sterilization volunteered for a tubal blocking procedure. An occlusive device of gamma polymerized hydrogel, a P-block, was applied in the isthmic part of the oviduct by trans-cervical hysteroscopy. Bilateral expulsion occurred in three and unilateral in six subjects. Six patients became pregnant. The P-block was in position from one week to 32 months. Histologically, the reaction to the P-block was first erosion and acute unspecific inflammation. Later there was a histiocytic and foreign-body reaction due to dissolution of the hydrogel. When the P-block was expelled no changes were present in the material.