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Metabolites of the tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone in smokers' urine

Carmella, S.G.; Akerkar, S.; Hecht, S.S.

Cancer Research 53(4): 721-724

1993

ISSN/ISBN: 0008-5472
PMID: 8428352
Document Number: 416013
Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 mu-g/24 h, respectively. The results of this study provide the first evidence for metabolites of tobacco-specific nitrosamines in human urine.

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