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Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen

Wood, M.W.; Seidler, F.J.; Slotkin, T.A.

Research Communications in Chemical Pathology and Pharmacology 80(3): 323-328

1993

ISSN/ISBN: 0034-5164
PMID: 8351412
Document Number: 414285
Oxygen therapy in preterm infants is associated with bronchopulmonary dysplasia, but the relative importance of oxygen toxicity as compared to adverse effects of intubation and mechanical ventilation, remains uncertain. In freely-breathing neonatal rats, exposure to 100% oxygen for as little as 2 hr produced a significant reduction in lung DNA synthesis, evaluated by [3H]thymidine incorporation, without a concomitant effect on [3H]leucine incorporation into protein. These results indicate that hyperoxia has a selective deleterious effect on mitosis in developing lung.

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Viotti, G.; Spigno, F.; De Lucchi, M. 1981: Hyperbaric oxygen and the lung. Pulmonary diffusion in divers with intense and long-term exposure Minerva Medica 72(22): 1391-1394
Krychniak-Soszka, A.; Wesołowski, S.; Kuś, J. 1997: Lung and pleural changes caused by exposure to asbestos Pneumonologia i Alergologia Polska 65(9-10): 676-684
Maritz, G.S.; Woolward, K. 1992: Effect of maternal nicotine exposure on neonatal lung elastic tissue and possible consequences South African Medical Journal 81(10): 517-519
Vineis, P.; Simonato, L. 1988: The proportion of tumors of the lung caused by occupational exposure: updating Epidemiologia E Prevenzione 10(35): 7-10
Rees, D.I.; Wansbrough, S.R. 1982: One-lung anesthesia: percent shunt and arterial oxygen tension during continuous insufflation of oxygen to the nonventilated lung Anesthesia and Analgesia 61(6): 507-512
Su, S.-b.; Tong, J. 2005: Research progress in related gene of lung cancer caused by radon exposure Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23(2): 144-146
Robertson, D. 1992: A review of ventilation-perfusion relationships in the neonatal lung. Part II: use of oxygenation indices to evaluate neonatal lung disease Neonatal Network: Nn 11(8): 57-60
Bang, A.; Deshmukh, M.; Baitule, S.; Duby, J. 2021: Decline in the Incidence of Neonatal Sepsis in Rural Gadchiroli, India During the Twenty-one Years (1998–2019) Following the Home-based Neonatal Care Field-trial Pediatric Infectious Disease Journal 40(11): 1029-1033
Belisario, A.; Raffi, G.B.; Beghi, M.; Briccoli, A. 1985: Round shadow in the lung of an unusual origin: chronic pneumonitis caused by occupational exposure to synthetic fibers Minerva Medica 76(19-20): 955-958
Vogtmann, C.; Böttger, H. 1972: Value of capillary oxygen partial pressure determination for the control of oxygen therapy in the neonatal period Kinderarztliche Praxis 40(11): 507-514
Yagi, Y.; Goto, Y.; Kuze, S. 1987: An accident of high oxygen concentration caused by a leak in the oxygen failure safety valve Masui. Japanese Journal of Anesthesiology 36(2): 257-260
David, R.J.; Siegel, E. 1983: Decline in neonatal mortality, 1968 to 1977: better babies or better care? Pediatrics 71(4): 531-540
Welty, S.E.; Jarriel, W.S.; Langston, C.; Hansen, T. 1995: Pre mortem analysis of lung injury and lung function in oxygen toxic rabbits Critical Care Medicine 23(2): 340-347
Langård, S. 2005: Nordic experience: expected decline in the incidence of mesotheliomas resulting from ceased exposure? La Medicina del Lavoro 96(4): 304-311
Stocks, J.; Godfrey, S. 1976: The role of artificial ventilation, oxygen, and CPAP in the pathogenesis of lung damage in neonates: assessment by serial measurements of lung function Pediatrics 57(3): 352-362
Adams, J.C.; Morehart, A.L. 1982: Decline and Death of Pinus spp. in Delaware Caused by Bursaphelenchus xylophilus Journal of Nematology 14(3): 382-385
Oguri, T.; Fujiwara, Y.; Ochiai, M.; Fujitaka, K.; Miyazaki, M.; Takahashi, T.; Yokozaki, M.; Isobe, T.; Ohune, T.; Tsuya, T.; Katoh, O.; Yamakido, M. 1998: Expression of lung-resistance protein gene is not associated with platinum drug exposure in lung cancer Anticancer Research 18(6a): 4159-4162
Frappier-Davignon, L.; St-Pierre, J. 1973: Combined effect of air pollution, occupational exposure, and tobacco habits in obstructive lung diseases. II. Food processing firm: no occupational exposure L'Union Medicale du Canada 102(7): 1542-1546
Modesto Alapont, V.; Pantoja Martínez, J. 2000: Neonatal resuscitation with 100% oxygen Anales Espanoles de Pediatria 53(3): 287-288
Lista, G.; Castoldi, F.; Azzali, A.; Fontana, P.; Menchini, M.; Compagnoni, G. 2002: What is new in neonatal resuscitation and in the use of oxygen La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics 24(6): 460-462