Evaluation of povidone-iodine alcoholic solution for operative site disinfection
Arata, T.; Murakami, T.; Hirai, Y.
Postgraduate Medical Journal 69(Suppl): S93-S96
1993
ISSN/ISBN: 0032-5473 PMID: 8290465 Document Number: 413689
A clinical investigation of povidone-iodine alcoholic solution on disinfectant efficacy at the operative site was carried out in comparison with poloxamer-iodine alcoholic solution and povidone-iodine aqueous solution. Bacterial samples obtained by the cylinder scrub method from 10 cm-2 of abdominal skin pre- and post-disinfection were filtered using a millipore membrane and cultured aerobically at 37 degree C for 48 hours. The antimicrobial efficacy of each product was expressed as the logarithmic reduction value (reduction factor) in resident bacterial counts. Significantly higher reduction factors (RF) of the total resident bacteria were obtained with povidone-iodine ethanol solution (RF 2.02) than with povidone-iodine aqueous solution (RF 1.17). No adverse reaction was observed with either preparation during the study period. It is concluded that povidone-iodine ethanol solution is a reasonable and effective antibacterial agent for pre-operative skin preparation.