Cerebral microdialysis in neurological and neurosurgical research and clinical application in neurology and neurosurgery
Mindermann, T.; Landolt, H.; Langemann, H.; Gratzl, O.
Schweizerische Rundschau für Medizin Praxis 82(1): 9-11
1993
ISSN/ISBN: 1013-2058 PMID: 8419993 Document Number: 413031
Microdialysis of the cerebral extracellular space (CES) provides information on the cortical metabolic state by measurement of the concentrations of metabolites and transmitters as well as of the extracellular pH. In trauma patients, this kind of monitoring should reveal damage from secondary cortical ischemia in an early, hopefully reversible state. The method further allows in vivo measurement of drug levels in the CES and investigation of their effect on metabolism. Although microdialysis has mainly been used experimentally, it is now beginning to be applied clinically. We report on our experience with both experimental and clinical work.