PreS-sequence of the hepatitis B virus envelope: molecular biology and immunology
Sominskaia, I.V.; Sergeeva, S.M.; Pumpen, P.P.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 3: 15-22
1993
ISSN/ISBN: 0208-0613 PMID: 8350877 Document Number: 412547
Current data on molecular biology and immunology of the proteins of hepatitis B viral capsid encoded by the preS-region of HBV genome are reviewed. Main attention is paid to study of the immune properties of the capsid proteins, to search of immune dominant epitopes encoded in preS-sequences. The medical and biological significance of the research is shown as exemplified by search of preS-antigens and anti-preS-antibodies in serum from patients suffering hepatitis B. The use of preS-sequences as components of vaccine preparations is discussed.