The use of sumatriptan in the treatment of migraine
Gross, M.
British Journal of Clinical Practice 47(4): 205-207
1993
ISSN/ISBN: 0007-0947 PMID: 8260340 Document Number: 411495
Sumatriptan is a selective agonist of 5-hydroxytryptamine receptors, recommended for the acute treatment of migraine. The 5-HT1 receptor subtype is found in the cranial vasculature of many species including humans, and causes vasoconstriction of these vessels. Sumatriptan as a highly potent 5-HT1 agonist selectively constricts large intracranial blood vessels and also blocks neurogenic inflammation. Those treating patients with severe or inconveniently timed attacks will find sumatriptan the drug of choice.