Giant cell tumor arising in Paget's disease of bone. Recurrences after 36 years
Singer, F.R.; Mills, B.G.
Clinical Orthopaedics and Related Research 293: 293-301
1993
ISSN/ISBN: 0009-921X PMID: 8339495 Document Number: 410569
A 96-year-old woman had both Paget's disease and a giant cell tumor of the same bone, the left scapula. Despite five surgical procedures, a full course of radiation therapy, and treatment with salmon calcitonin, human calcitonin, and finally disodium etidronate, the tumor has recurred over a 36-year period. The characteristic viral-like nuclear and cytoplasmic inclusions found in the osteoclasts of Paget's disease were found in the tumor giant cells, in specimens excised over an eight-year period, and in specimens obtained during orthopedic procedures on her other pagetic bone lesions over 12 years.