Epidemiology of resistance to diaminopyrimidines
Goldstein, F.W.; Acar, J.F.
Journal of ChemoTherapy 5(6): 453-457
1993
ISSN/ISBN: 1120-009X PMID: 8195837 Document Number: 410338
Resistance to trimethoprim emerged in Enterobacteriaceae and later in other Gram-negative and Gram-positive bacteria within two years of the clinical introduction of the drug. Resistance is borne in many different replicons often present in multiply-resistant epidemic-bacteria. The incidence of trimethoprim resistance is highly variable, depending upon methodology, type of patients, local epidemiology: this can be illustrated by the high variation-of trimethoprim resistance among Salmonella, Shigella or MRSA in various countries and by the incidence of resistance in penicillin-resistant Streptococcus pneumoniae.