Regional metabolism of 5-hydroxytryptamine in brain under acute and chronic heat stress
Dey, S.; Dey, P.K.; Sharma, H.S.
Indian Journal of Physiology and Pharmacology 37(1): 8-12
1993
ISSN/ISBN: 0019-5499 PMID: 8449553 Document Number: 410222
The metabolic alteration of 5-HT in four different regions of rat brain and plasma was studied under acute and chronic heat stress. A generalised evaluation of 5-HT in all the brain regions along with high plasma level was observed in animals subjected to 4 hour heat stress at 38 degree C. Such elevation of brain 5-HT may be due to entry of plasma 5-HT into the brain owing to breakdown of blood-brain barrier (BBB). In heat adapted rats, where BBB remained unaffected, no increase in brain 5-HT was observed, rather a significantly low level was maintained both in plasma and brain tissue.