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cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily

Iwamoto, T.; Taniguchi, M.; Asai, N.; Ohkusu, K.; Nakashima, I.; Takahashi, M.

Oncogene 8(4): 1087-1091

1993

ISSN/ISBN: 0950-9232
PMID: 8455936
Document Number: 409875
We report the nucleotide sequence of the mouse ret proto-oncogene (proto-ret) and the deduced amino acid sequence. It encodes a transmembrane tyrosine kinase of 1115 amino acids that shows 83% homology with the human proto-Ret protein. The amino acid sequence revealed that the structures of the extracellular domain as well as the tyrosine kinase domain are similar in human and mouse proto-Ret proteins. Interestingly, the extracellular domains of both humans and mouse proto-Ret proteins contain a cadherin-related sequence that is known to be important for Ca-2+-dependent homophilic binding of the cadherins. When we examined transcription of the proto-ret gene in a variety of mouse tissues, it was detected in lymph nodes of C3H/H3J-gld/gld mice and in normal mouse spinal cord. Furthermore, its transcription was found in the Neuro-2a mouse neuroblastoma cell line but not in 13 other rodent cell lines surveyed. Western blot anlaysis showed that proto-Ret proteins are expressed as 140-kDa and 160-kDa glycoproteins in Neuro-2a cells.

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