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Xenotransplantation: baboons as potential liver donors? Scientific and ethical issues

Chiche, L.; Adam, R.; Caillat-Zucman, S.; Castaing, D.; Bach, J.F.; Bismuth, H.

Transplantation 55(6): 1418-1421

1993

ISSN/ISBN: 0041-1337
PMID: 8516828
Document Number: 409868
The dramatic development of liver transplantation compared to a relative shortage of donors has brought a renewed interest to xenotransplantation. Because of anatomical and immunological compatibilities, nonhuman primates are the most appropriate donors. The aim of this work was to analyze the different problems of a baboon-to-man liver xenotransplantation. Thirty baboons bred in a French Primatology Center were studied. The analysis of anatomical, microbiological, and immunological data showed that only 8 baboons out of 30 were suitable as donors for xenotransplantation. Considering these data and the ethical issues, the actual feasibility of xenotransplantation programs is discussed.

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