Possible markers of the progression and ulcerogenesis of stomach cancer
Serov, V.V.; Iushkov, P.V.; Ivanov, P.K.
Arkhiv Patologii 55(2): 9-12
1993
ISSN/ISBN: 0004-1955 PMID: 7980072 Document Number: 409214
The stomachs from 40 patients operated on for gastric cancer and chronic ulcer were studied immunohistochemically using antibodies to CEA, galactosyl transferase, pepsinogens A and C, gastrin, alpha 1-antitrypsin. CEA and galactosyl transferase of the cancer parenchyma are shown to mark tumor progression. The ratio of alpha 1-antitrypsin to pepsinogens in gastric epithelium and cancer cells probably plays a role in ulcerogenesis of normal mucosa and tumor tissue. Gastrin in carcinoma tissue is both an ulcerogenesis factor and a marker of tumor progression, an unfavourable prognosis of gastric cancer.