Literature review on fenofibrate
Martínez Triguero, M.L.
Anales de Medicina Interna 10(4): 195-199
1993
ISSN/ISBN: 0212-7199 PMID: 8513089 Document Number: 408864
Phenofibrate is one of the hypolipidemic agents derived from the fibric acid that is more frequently used nowadays, because it has shown several advantages over other hypolipidemics belonging to the same family, and a greater power, which allows to obtain greater reductions in LDL levels and less side effects. Its mechanism of action affects basically the metabolism of triglycerides, with a reduction in their synthesis and an increase in their catabolism, being able to act as well on the metabolism of cholesterol, mainly at the level of its catabolism. The phenofibrate, thus, has apparently shown a significant hypolipidemic effectivity, decreasing plasmatic levels of c-LDL and triglycerides and increasing levels of c-HDL, resulting in a less atherogenic lipidic profile.