The use of Russian allergoids for the specific immunotherapy of pollinosis
Fradkin, V.A.; Roshal', N.I.; Goriachkina, L.A.; Nikonorova, M.V.; Astaf'eva, N.G.; Luss, L.V.; Raĭkis, V.N.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 101-105
1993
ISSN/ISBN: 0372-9311 PMID: 8067129 Document Number: 408378
For three years 128 pollinosis patients received specific immunotherapy with cereals, weed and tree pollen allergens manufactured by the Scientific and Industrial Amalgamation "Allergen" (Stavropol). For comparison, a group of 42 patients was treated with the corresponding allergens according to the commonly used treatment scheme. Patients who had earlier undergone treatment with water-saline extracts of allergens, that proved to be ineffective, formed a special group. In sensitive patients reaction to the skin test with allergoids was by half less pronounced than reaction to the skin test with allergens. In allergometric titration on the nasal mucosa, reaction to the introduction of allergoids could be registered when they were used at a 10- to 100-fold higher concentration than allergens. The course of specific immunotherapy with allergoids was found to lead to a decrease in the level of allergen-specific IgE antibodies (p > 0.05) and total IgE (p < 0.01). An increase in the level of IgG antibodies was noted (p < 0.01). Specific immunotherapy with allergoids was more effective than that with water-saline extracts of allergens. The use of allergoids made it possible to prescribe specific immunotherapy to a wider circle of patients.