The role of calcium homeostasis and calcium currents in ethanol actions on central mammalian neurons
Carlen, P.L.; Jahromi, S.S.; Valiante, T.A.; Velumian, A.A.; Weiner, J.L.; Zhang, L.
Alcohol and Alcoholism . Suppl 2: 395-401
1993
ISSN/ISBN: 1358-6173 PMID: 7748329 Document Number: 408165
The ubiquitous role of calcium in ethanol actions measured electrophysiologically in central neurons is discussed. Acute ethanol administration to rat hippocampal neurons in vitro causes a hyperpolarization, increased AHPs, increased EPSPs and IPSPs, decreased modelled electronic interneuronal coupling, decreased high threshold Ca2+ currents, increased Ik, and increased synaptic GABAA currents. Alcohol withdrawal reverses some of these actions. Ca2+ is implicated in all of the above ethanol mediated effects.