Fibrin adhesive in radical mastectomy
Udén, P.; Aspegren, K.; Balldin, G.; Garne, J.P.; Larsson, S.A.
European Journal of Surgery 159(5): 263-265
1993
ISSN/ISBN: 1102-4151 PMID: 8103359 Document Number: 408017
Objective: To find out if fibrin adhesive glue applied locally would reduce the incidence of seroma after modified radical mastectomy for breast cancer. Design: Prospective randomised study. Setting: City hospital, Sweden. Subjects: 68 women undergoing modified radical mastectomy with axillary clearance for breast cancer. Main outcome measures: Amount of postoperative drainage, number of seromas aspirated volumes; length of hospital stay, influence of surgeon operating. Results: Seromas developed in a total of 40/68 patients (59%), 23/36 in the fibrin adhesive group (64%) and 17/32 in the control group (53%); p = 0.5 (95% confidence interval of the difference-0.13 to 0.34). There were no significant differences in the volume of aspirations or in hospital stay. The skill of the surgeon influenced the incidence of seromas, but the differences were not significant (p = 0.5). Conclusion: Local application of a fibrin adhesive glue has no effect on the incidence of seroma formation after modified radical mastectomy.