DNA as a prognostic factor in colorectal cancer. A retrospective analysis of 34 patients
Bianchi, A.; Mallofre, C.; Serrano, A.; Suñol, J.; Barja, J.; Ubach, M.
Revista Espanola de Enfermedades Digestivas Organo Oficial de la Sociedad Espanola de Patologia Digestiva 84(2): 100-104
1993
ISSN/ISBN: 1130-0108 PMID: 8398367 Document Number: 407976
We study the tumoral DNA as a prognostic factor in patients operated for colo-rectal cancer. Retrospective. We analyze by flow cytometry the DNA content of tumoral tissue: Ploidy, DNA Index, Proliferative Index, S Phase. 34 operated patients, for colo-rectal cancer, with a minimum 3 years of follow-up. Ploidy doesn't show any relation with other prognostic factors. Only Dukes C aneuploid patients had more positive nodes than diploid. Ploidy was not related to better evolution or survival. Neither DNA Index, Proliferative Index and S Phase were related to the evolution of the disease. The DNA study by flow cytometry has no better prognostic value then other classical factors.