CD7, CD4 and myeloid antigen-positive acute lymphoblastic leukemia
Nakase, K.; Kita, K.; Sekine, T.; Otsuji, A.; Shirakawa, S.; Tsuji, K.; Miyanishi, E.; Asou, H.; Kamada, N.
International Journal of Hematology 59(1): 41-46
1993
ISSN/ISBN: 0925-5710 PMID: 7909241 Document Number: 407304
We report a case of acute lymphoblastic leukemia (ALL, FAB-L2) with unique cellular characteristics. Leukemic cells were negative for various cytochemical stainings except acid phosphatase. Immunophenotypic studies revealed CD7+, CD4+, CD8-, CD2+, CD3-, CD13+, CD25+, CD33+ and CD34+. The immunoglobulin heavy chain and T-cell receptor beta, gamma and delta chain genes were germline configurations. This patient had a karyotype of complex abnormalities involving Nos. 5 and 7. Leukemic cells showed a prominent response to interleukin-3, granulocyte macrophage colony stimulating factor (GM-CSF) and G-CSF with partial granulocytic differentiation in a colony assay. A binding assay confirmed the presence of both high and low affinity receptors for GM-CSF. These findings suggest that CD7+CD4+CD8-CD3- putative T-cell precursors may retain the capacity to differentiate to myeloid lineage.