Effects of enalapril, an ACE-inhibitor, on bronchial responsiveness in asthmatics
Talwar, D.; Jindal, S.K.
Indian Journal of Physiology and Pharmacology 37(3): 217-220
1993
ISSN/ISBN: 0019-5499 PMID: 8276499 Document Number: 406989
To assess the effects of enalapril on bronchial responsiveness, we studied ten stable asthmatics and five healthy normal volunteers. Spirometry and methacholine bronchoprovocation dose (PC-20) were measured before and after oral administration of 20 mg enalapril. Significant hypotensive effect was observed in all. More than two fold (2.73) increase in bronchial responsiveness was observed in the asthmatics (P lt 0.01) without significant change in the expiratory flows. PC-20 after enalapril fell by 56.8+- 23.0% of baseline value (P lt 0.001). No significant change was observed in spirometric parameters and bronchial responsiveness in normal subjects. We conclude that enalapril significantly enhances BR and cannot be used safely in treatment of hypertension in asthmatics.