DNA cleavage by benzidine derivatives in weak acidic conditions
Yamashita, R.; Namihira, T.; Nakamura, Y.
Nucleic Acids Symposium Series 29: 91-92
1993
ISSN/ISBN: 0261-3166 PMID: 8247809 Document Number: 406556
A plasmid DNA was cleaved by aromatic amines in weak acidic conditions at 37 degrees C. The cleavage was not inhibited by 4 hydroxylradical scavengers, EDTA, SOD and catalase. It was strongly influenced by the pH value of the reaction buffer. The decrease of Form I DNA in this reaction obeyed good first-order kinetics.
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