Rationale for the utilization of interleukin-4, an immune-recognition induced cytokine, in cancer immunotherapy
Costello, R.; Lipcey, C.; Olive, D.
European Journal of Medicine 2(1): 54-57
1993
ISSN/ISBN: 1165-0478 PMID: 8258007 Document Number: 406443
Interleukin-2 use for advanced cancer treatment has demonstrated that cytokines are of interest not only in the field of immunology but also in oncology. Interleukin-2 is only one member of the ever-growing family of immune recognition-induced lymphokines. Interleukin-4, a cytokine with pleiotropic effects, shares some common properties with interleukin-2. Availability of recombinant interleukin-4 has led to a better knowledge of this cytokine's functions, and also makes clinical trials possible. This brief review discusses the in vitro and in vivo data that support a potential use of interleukin-4 in cancer immunotherapy.