The clinical evaluation of UF-021, a new prostaglandin related compound, in low tension glaucoma patients
Fujimori, C.; Yamabayashi, S.; Hosoda, M.; Hosaka, O.; Makino, F.; Henmi, T.; Tsukahara, S.; Ueno, R.
Nippon Ganka Gakkai Zasshi 97(10): 1231-1235
1993
ISSN/ISBN: 0029-0203 PMID: 8256677 Document Number: 406020
We administered UF-021 isopropyl unoprostone (Rescula) ophthalmic solution, a new prostaglandin-related compound developed as an anti-glaucoma agent, to 13 low tension glaucoma patients for 24 weeks, and clinically evaluated the effect of the intraocular pressure (IOP) reduction, visual field change, and side effects of the agent. Intraocular pressure was reduced in 11 out of 12 patients who were studied for statistical analysis. In these 12 patients, significant IOP reduction was recognized in the mean IOP for 24 weeks after the administration of UF-021. No side effects were detected in any of the 13 patients. From these results, UF-021 could be used as a new anti-glaucoma agent for low tension glaucoma, and also safer than many other anti-glaucoma agents.