Administration and dosage of iohexol, a nonionic contrast medium, for dynamic renal computed tomography
Tsugaya, M.; Sakagami, H.; Mogami, T.; Ohtaguro, K.; Hirao, N.; Kato, F.; Kato, J.; Hori, T.; Iwase, Y.
Hinyokika Kiyo. Acta Urologica Japonica 39(8): 687-693
1993
ISSN/ISBN: 0018-1994 PMID: 8379468 Document Number: 406004
We investigated the optimal method of administering iohexol, which contains 300 mg iodine/ml (Omnipaque 300), a nonionic contrast medium, to maintain adequate renal contrast while reducing artifacts during dynamic CT scanning. In this study, 76 patients with renal disease received 10 apprx 50 ml of iohexol as follows: group I (14 patients), 20 ml injected as an intravenous bolus for 5 sec, followed by 30 ml intravenous drip infusion for 5 min; group II (18 patients), bolus of 20 ml injected for 5 sec; group III (13 patients), 20 ml diluted with sterile water (total volume 40 ml), and injected as a bolus for 8 sec; group IV (15 patients), 20 ml injection for 5 sec followed by intravenous drip infusion of 200 ml of Hartmann-Ringer's solution given at maximum speed; and group V (14 patients), 10 ml diluted with sterile water (total volume 20 ml) injected as a bolus for 5 sec. We found that corticomedullary differentiation was most distinct on the images obtained from group IV. We concluded that a lower concentration of iohexol (150 mg iodine/ml) given by intravenous fluid loading can provide superior CT images.