Glycosylation of alpha 1-acid glycoprotein in systemic onset juvenile rheumatoid arthritis and acute bacterial infection: value in differential diagnosis
Fassbender, K.; Michels, H.; Zepp, F.; Zimmerli, W.; Aeschlimann, A.; Mackiewicz, S.; Müller, W.
Journal of Rheumatology 20(1): 123-127
1993
ISSN/ISBN: 0315-162X PMID: 8441143 Document Number: 405975
Agarose based affinity immunoelectrophoresis with free concanavalin A (Con-A) as ligand was used to examine the microheterogeneity of alpha 1-acid glycoprotein in sera of patients with systemic onset juvenile rheumatoid arthritis (JRA) and acute bacterial infections. In JRA, a decreased proportion of Con-A reactive alpha 1-acid glycoprotein variants was found when compared to healthy control. In contrast, acute bacterial infection showed an increased reactivity. Investigation of glycosylation may be useful in the differential diagnosis of systemic onset JRA and acute bacterial infection.