Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol
Martí, M.L.; De los Santos, A.R.; Di Girolamo, G.; Gil, M.; Manero, E.O.; Fraga, C.
International Journal of Tissue Reactions 15(5): 207-213
1993
ISSN/ISBN: 0250-0868 PMID: 8077090 Document Number: 405929
Lysine clonixinate (LC), an effective and well tolerated non-morphinic analgesic whose mechanism of action is basically due to the inhibition of cyclo-oxygenase, was assessed with a double-blind randomized dummy design versus paracetamol (P) on 200 patients suffering from pain after minor dental surgery. Patients received according to their needs 1 or 2 tablets of 125 mg lysine clonixinate or 500 mg paracetamol every 8h during 48h or until pain relief Both groups, each composed of 100 patients, were comparable in terms of demographic conditions (t test) initial symptoms (chi-square test), characteristics of the extracted dental pieces, surgical complications and wound treatment (chi-square test). Pain intensity scores and daily average intake of tablets (3 4/day) documented in the patients' diary revealed no statistically significant differences between the two treatments (chi-square test). It was found that spontaneous pain measured using a visual analogue scale (VAS) decreased significantly in both treatment groups at the 24-h control examination. The following values were observed in the LC group: baseline 4.38 +- 1.7; 24-h * 1.20 +- 1.4; 48-h *0.36 +- 1.2 In the P group the values were: baseline 4.28 +- 1.6; 24-h * 1.11 +- 1.4; 48-h *0.30 +- 0.7 (*p lt 0.05). Other variables like facial swelling and night pain, evaluated on a score from 0 to 4 and symptom presence or absence respectively, showed a similar response. No statistically significant differences were found between the two treatments in the evolution of spontaneous pain (t test), night pain, facial swelling and assessment of efficacy and tolerance according to the odontologist's and the patient's opinion 48 h after medication (chi-square test). Minor side-effects affected digestive and nervous systems: they were of slight intensity Two patients were wrongly incorporated because they compiled with exclusion criteria. No significant differences were found between the treatment groups (chi-square test) in the proportion of patients who showed adverse effects due to the respective treatments.
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