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A selection of biological indicators in occupational exposure to toluene and xylene

Skender, L.; Karacić, V.; Bosner, B.

Arhiv Za Higijenu Rada i Toksikologiju 44(1): 27-33

1993

ISSN/ISBN: 0004-1254
PMID: 8347098
Document Number: 405764
Results of a comparative study of occupational exposure to toluene and xylene are presented. The study was carried out in a group of 24 workers from a paint factory and aimed to determine the most appropriate exposure indicators for use in biological monitoring. Measurements included toluene and xylene in blood and their metabolites in urine. Toluene in blood proved to be the best indicator of toluene exposure, and both xylene in blood and its only major metabolite methylhippuric acid in urine to be reliable indicators of xylene exposure. The validity of hippuric acid and o-cresol as toluene exposure indicators has not been confirmed.

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