Multiple antibiotic resistance in Haemophilus influenzae related to serogroup B
Campos, J.; Seuba, T.; Trujillo, G.; Rodríguez, A.; Roca, J.
Enfermedades Infecciosas y Microbiologia Clinica 11(10): 552-554
1993
ISSN/ISBN: 0213-005X PMID: 8142505 Document Number: 405567
To study the association between multiply antibiotic resistance in Haemophilus influenzae and H. influenzae type B, and to describe levels and patterns of antibiotic resistance. Statistical analysis and susceptibility of 231 H. influenzae strains (52 type B and 179 non-typable ) isolated consecutively from pediatric patients. Resistance levels for type B and non-typable strains were: Ampicillin, 55.3% vs 28.8%; Chloramphenicol, 44.7% vs 9.2%; Ampicillin plus chloramphenicol, 40.4% vs 7.6%; cotrimoxazole, 89.3% vs 67.4%; resistance to six or more antibiotics, 36.0% vs 3.8%. Multiply antibiotic resistance in H. influenzae is strongly associated with type B strains, with age of 4 or younger, and with isolation from CSF or blood. Resistance is sustained over long periods of time.