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Oral ciprofloxacin therapy in juvenile patients with cystic fibrosis--results of a prospective pilot study

Sollich, V.; Klöditz, E.; Schuster, R.; Handrick, W.; Brömme, S.; Rumler, W.; Patsch, R.; Kharari, H.; Spencker, F.B.

Kinderarztliche Praxis 61(6): 211-214

1993

ISSN/ISBN: 0023-1495
PMID: 8411847
Document Number: 405546
Efficacy and safety of oral ciprofloxacin were studied in a prospective study at three cystic fibrosis centres, covering 24 in-patients suffering from cystic fibrosis and acute bronchopulmonary exacerbation. The patients were between 10 and 17 years of age. Pseudomonas infection was present in 75% of these patients. Despite frequent persistence of the pathogens, clinical improvement was noted in 75% of the treated children. A definite increase of the average MIC was not seen in 20 cases of persisting strains. No serious side effects occurred during the 14-day oral treatment course. Ciprofloxacin is a useful alternative to conventional parenteral treatment with antibiotics in patients suffering from cystic fibrosis and infections of the airways.

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