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Low insulin secretion in decompensated liver cirrhosis with diabetes mellitus

Sampelean, D.; Motocu, M.

Romanian Journal of Internal Medicine 31(4): 265-269

1993

ISSN/ISBN: 1220-4749
PMID: 8148778
Document Number: 405251
The present study aimed to investigate the pathogenesis of altered glucose tolerance frequently observed in liver cirrhosis by means of oral glucose tolerance test (OGTT) and i.v. glucagon followed by determining the immunoreactive insulinemia and insulinogenic index (Seltzer). In these conditions of beta islet cells upper limit stimulation a low insulin secretion was found in decompensated liver cirrhosis with alteration of the glucose tolerance (DM or IGT) and a tendency toward hepatic resistance to i.v. glucagon.

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