Therapeutic drug monitoring: lithium levels
Henigan, M.H.
Journal of the American Osteopathic Association 92(11): 1322; Author Reply 1324 1328
1992
ISSN/ISBN: 0098-6151 PMID: 1289303 Document Number: 405174
Lithium has been used in the treatment of mania sincd 1949. Although its effectiveness is well recognized, the mechanism by which it stabilizes manic behavior is not well understood. In addition, it has some serious toxic properties combined with a narrow therapeutic range. For this reason, monitoring of serum lithium levels is mandatory. Suggested mechanisms of action and protocols for monitoring of serum levels are presented.